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Information contained in the following UpToDate Talk podcasts was current at the time of initial release. However, this content is not maintained or updated. For current clinical recommendations, please always consult UpToDate Online. Please note that we are no longer producing new clinical podcasts.
UpToDate faculty discuss important changes to the practice of medicine based in our clinical podcasts. Our contributors are recognized physician leaders in their fields and offer their expertise regarding each update and its impact on clinical practice.
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This is the complete archive for the UpToDate Clinical Talk Podcasts.
Complications of t1 and t2 diabetes diagnosed in childhood; Gene therapy for sickle cell disease
Date Released: Jun 28 2017
Dr. Joseph Wolfsdorf discusses complications related to type 1 and type 2 diabetes in pediatric patients, and Dr. Michael DeBaun discusses a report of gene therapy for sickle cell disease. Dr. Nancy Sokol hosts.


Segment on diabetes in children (Dr. Wolfsdorf):
- Dabelea D, Stafford JM, Mayer-Davis EJ, et al. Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood. JAMA 2017; 317:825.
Segment on gene therapy for sickle cell disease (Dr. DeBaun):
- Ribeil JA, Hacein-Bey-Abina S, Payen E, et al. Gene Therapy in a Patient with Sickle Cell Disease. N Engl J Med 2017; 376:848.
Joseph I Wolfsdorf, MB, BCh Nothing to disclose
Michael R DeBaun, MD, MPH Nothing to disclose
Long-term follow-up of imatinib for CML; Ocrelizumab for primary progressive multiple sclerosis
Date Released: Jun 14 2017
This episode features Dr. Richard Larson discussing the long-term outcomes of imatinib treatment for chronic myeloid leukemia, and Dr. Francisco Gonzalez-Scarano discussing the use of ocrelizumab for treatment of primary progressive multiple sclerosis. Dr. Jennifer Mitty hosts.


Segment on Long-term follow-up of Imatinib in chronic myeloid leukemia (Dr. Richard Larson) :
- Hochhaus A, Larson RA, Guilhot F, et al. Long-term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia. N Engl J Med 2017; 376:917.
Segment on Ocrelizumab for primary progressive multiple sclerosis (Dr. Francisco González-Scarano):
- Montalban X, Hauser SL, Kappos L, et al. Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis. N Engl J Med 2017; 376:209.
Francisco González-Scarano, MD Equity Ownership/Stock Options: Multiple, but traded by advisors without personal input [Pharmaceutical]. Other Financial Interests: NeuroLink [Venture Capital].
Richard A Larson, MD Grant/Research/Clinical Trial Support: Amgen [leukemia (blinatumomab)]; Astellas [leukemia (gilteritinib)]; Erytech [leukemia (eryaspase)]; Ariad [leukemia (ponatinib)]; Novartis [leukemia (nilotinib)]; Ambit Bioscience [leukemia (quizartinib)]; Daiichi Sankyo [leukemia (quizartinib)]; Celgene [leukemia (AG-221)]. Consultant/Advisory Boards: Novartis [leukemia (imatinib, nilotinib)]; Ariad Data Safety Monitoring Board [leukemia (ponatinib)]; CVS/Caremark [leukemia (drug prior authorization program)]; Pfizer [leukemia (gemtuzumab ozogamicin, inotuzumab)]; Celgene Data Safety Monitoring Board [leukemia (azacitidine, durvalumab)]; Bristol Meyers Squibb Data Safety Monitoring Board [leukemia (dasatinib)]; Amgen [leukemia (blinatumomab)]; Astellas [leukemia (gilteritinib)]; Jazz [leukemia (CPX-351)].
UpToDate Pathways: Initial management of hypertension
Date Released: Jun 7 2017
This episode features Dr. George Bakris discussing the initial management of hypertension and factors that should be considered in optimizing initial therapy for an individual patient. Dr. Nancy Sokol hosts. Listen to the full podcast by pressing the Play Button below.

George Bakris, MD Grant/Research/Clinical Trial Support: Bayer; Boehringer Ingelheim; Relypsa; Vascular Dynamics [Diabetic neuropathy, diabetes, hypertension (Empagliflozin, patiromer)]. Consultant/Advisory Boards: AstraZeneca; Bayer; Boehringer Ingelheim; Relypsa; Vascular Dynamics; Merck; Pfizer; NxStage [Diabetic neuropathy, diabetes, hypertension (Empagliflozin, patiromer)].
UpToDate Pathways: Management of osteoporosis in women
Date Released: Jun 7 2017
This episode features Dr. Clifford Rosen, discussing the management of a postmenopausal woman who’s been found to have an abnormal bone density study on screening for osteoporosis. Dr. Nancy Sokol hosts. Listen to the full podcast by pressing the Play Button below.

Clifford J Rosen, MD Disclosure: Grant/Research/Clinical Trial Support: Alexion [Hypophosphatasia (Recombinant alkaline phosphatase)].