Clinical Podcasts Archive


Information contained in the following UpToDate Talk podcasts was current at the time of initial release. However, this content is not maintained or updated. For current clinical recommendations, please always consult UpToDate Online. Please note that we are no longer producing new clinical podcasts.

UpToDate faculty discuss important changes to the practice of medicine based in our clinical podcasts. Our contributors are recognized physician leaders in their fields and offer their expertise regarding each update and its impact on clinical practice.

Support for UpToDate Talk is provided by UpToDate, Wolters Kluwer. UpToDate is entirely funded by the subscriptions of its users and does not accept advertising or funding unrelated to subscriptions. The opinions in such podcasts are entirely those of the discussants, and these discussants are authors and editors for UpToDate. View the UpToDate conflict of interest policy.

This is the complete archive for the UpToDate Clinical Talk Podcasts.

Duration of adjuvant endocrine therapy for breast cancer; Treatment for binge eating disorder

Date Released: Sep 14 2016

This episode features Dr. Harold Burstein discussing a Practice Changing Update related to the duration of adjuvant hormone therapy for non-metastatic, post-menopausal breast cancer (starts at 01:01); and Dr. Joel Yager discussing a recent systematic review of treatment for binge eating disorder (starts at 15:04). Dr. Nancy Sokol hosts.

Dr. BursteinDr. Harold Burstein is Associate Professor of Medicine at the Harvard Medical School and a medical oncologist at the Dana Farber Cancer Institute and Brigham and Women’s Hospital in Boston, MA.
Dr. YagerDr. Joel Yager is Professor of Psychiatry at the University of Colorado School of Medicine.

Segment on adjuvant endocrine therapy for breast cancer (Dr. Burstein):

  1. Goss PE, Ingle JN, Pritchard KI, et al. Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years. N Engl J Med 2016; 375:209

Segment on binge eating disorder (Dr. Yager):

  1. Brownley KA, Berkman ND, Peat CM, et al. Binge-Eating Disorder in Adults: A Systematic Review and Meta-analysis. Ann Intern Med 2016.


Harold Burstein, MD, PhD Nothing to disclose

Joel Yager, MD Nothing to disclose


Sexual dysfunction in women; Pediatric gastroenteritis; Childhood obesity

Date Released: Aug 11 2016

In this episode, Dr. Jan Shifren discusses flibanserin for treatment of sexual dysfunction in women (starts at 01:13); Dr. Stephen Freedman discusses use of diluted apple juice for hydration in children with mild gastroenteritis (starts at 11:31); and Dr. Kathleen Motil discusses the association between obesity in adolescence and cardiovascular mortality in adulthood (starts at 20:53). Dr. April Eichler hosts.

Dr. ShifrenDr. Jan Shifren is Associate Professor of Obstetrics, Gynecology, and Reproductive Biology at Harvard Medical School and director of the Midlife Women’s Health Center at the Massachusetts General Hospital.
Dr. FreedmanDr. Stephen Freedman is Associate Professor of Pediatrics at Alberta Children’s Hospital and the University of Calgary.
Dr. MotilDr. Kathleen Motil is Professor of Pediatrics at Baylor College of Medicine.

Segment on sexual dysfunction in women (Dr. Shifren):

  1. Jaspers L, Feys F, Bramer WM, et al. Efficacy and Safety of Flibanserin for the Treatment of Hypoactive Sexual Desire Disorder in Women: A Systematic Review and Meta-analysis. JAMA Intern Med 2016; 176:453.

Segment on pediatric gastroenteritis (Dr. Freedman):

  1. Freedman SB, Willan AR, Boutis K, Schuh S. Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial. JAMA 2016; 315:1966.

Segment on childhood obesity (Dr. Motil):

  1. Twig G, Yaniv G, Levine H, et al. Body-Mass Index in 2.3 Million Adolescents and Cardiovascular Death in Adulthood. N Engl J Med 2016; 374:2430.


Jan L Shifren, MD Consultant/Advisory Boards: New England Research Institutes [Epidemiological research related to genitourinary syndrome of menopause].

Stephen Freedman, MDCM, MSc Grant/Research/Clinical Trial Support: Novartis [antiemetics (ondansetron)].

Kathleen J Motil, MD, PhD Nothing to disclose.


Multi-drug resistant tuberculosis; Ischemic cardiomyopathy; Chronic insomnia

Date Released: Jul 13 2016

In this episode, Dr. Neil Schluger will discuss new WHO recommendations for treatment of multi-drug resistant tuberculosis (starts at 00:52); Dr. Wilson Colucci will discuss the STITCHES trial for coronary artery bypass surgery in ischemic cardiomyopathy (starts at 14:22); and Dr. Michael Bonnet will discuss cognitive behavioral therapy for insomnia (CBT-I) (starts at 25:34).

Resources for insomnia segment:

Rules for good sleep
Sleep restriction rules
Sample sleep diary

Dr. SchlugerDr. Neil Schluger is Professor of Medicine and Professor of Epidemiology and Environmental Health Sciences in the College of Physicians and Surgeons at the Columbia University Medical Center, where he is also Chief of Pulmonary and Critical Care Medicine.
Dr. ColucciDr. Wilson Colucci is Professor of Medicine and Physiology and Chief of Cardiovascular Medicine at the Boston University School of Medicine.
Dr. BonnetDr. Michael Bonnet is a clinical psychologist and Professor of Neurology at Wright State University.

Segment on multi-drug resistant tuberculosis (Dr. Schluger):

  1. World Health Organization. WHO treatment guidelines for drug-resistant tuberculosis: 2016 update. WHO, Geneva 2016. (Accessed on May 17, 2016).
  2. Aung KJ, Van Deun A, Declercq E, et al. Successful '9-month Bangladesh regimen' for multidrug-resistant tuberculosis among over 500 consecutive patients. Int J Tuberc Lung Dis 2014; 18:1180.

Segment on coronary ischemic cardiomyopathy (Dr. Colucci):

  1. Velazquez EJ, Lee KL, Jones RH, et al. Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy. N Engl J Med 2016; 374:1511.

Segment on chronic insomnia (Dr. Bonnet):

  1. Qaseem A, Kansagara D, Forciea MA, et al. Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med 2016.


Neil W Schluger, MD Nothing to disclose

Wilson S Colucci, MD Grant/Research Support: Novartis; RiboCor [Heart failure]. Consultant/Advisory Boards: Novartis; Merck; Mast Pharmaceuticals; Cardioxyl Pharmaceuticals [Heart failure]. Speaker's Bureau: Novartis [Heart failure].

Michael H Bonnet, PhD Grant/Research/Clinical Support: Merck [Insomnia (suvorexant)].


Zika virus; Therapy for chronic asthma; Stroke prevention in sickle cell disease

Date Released: Jun 8 2016

This episode features Dr. Martin Hirsch discussing the association between Zika virus and Guillain Barré syndrome (starts at 01:18); Dr. Christopher Fanta discussing the use of combination inhaled long-acting beta agonists and corticosteroids for asthma (starts at 10:08); and Dr. Donald Mahoney discussing stroke prevention with hydroxyurea in children with sickle cell disease (starts at 22:32).

Dr. HirschDr. Martin Hirsch is a Professor of Medicine at the Harvard Medical School, Professor of Infectious Diseases and Immunology at the Harvard School of Public Health, and Senior Physician in Infectious Diseases at the Massachusetts General Hospital in Boston.
Dr. FantaDr. Christopher Fanta is Professor of Medicine at the Harvard Medical School, Director of the Partners' Asthma Center, and Pulmonologist at Brigham Women's Hospital in Boston.
Dr. MahoneyDr. Donald Mahoney, Jr. is Professor of Pediatrics at Baylor College of Medicine, and Director of the Texas Children's Hematology Center.

Segment on Zika virus (Dr. Hirsch):

  1. Cao-Lormeau VM, Blake A, Mons S, et al. Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 2016; 387:1531.

Segment on therapy for chronic asthma (Dr. Fanta):

  1. Stempel DA, Raphiou IH, Kral KM, et al. Serious asthma events with fluticasone plus salmeterol versus fluticasone alone. N Engl J Med 2016; 374:1822

Segment on stroke prevention in sickle cell disease (Dr. Mahoney):

  1. Ware RE, Davis BR, Schultz WH, et al. Hydroxycarbamide versus chronic transfusion for maintenance of transcranial Doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. Lancet 2016; 387:661.
  2. Close

Martin S Hirsch, MD Nothing to disclose

Christopher H Fanta, MD Nothing to disclose

Donald H Mahoney, Jr, MD Nothing to disclose