Clinical Podcasts Archive


Information contained in the following UpToDate Talk podcasts was current at the time of initial release. However, this content is not maintained or updated. For current clinical recommendations, please always consult UpToDate Online. Please note that we are no longer producing new clinical podcasts.

UpToDate faculty discuss important changes to the practice of medicine based in our clinical podcasts. Our contributors are recognized physician leaders in their fields and offer their expertise regarding each update and its impact on clinical practice.

Support for UpToDate Talk is provided by UpToDate, Wolters Kluwer. UpToDate is entirely funded by the subscriptions of its users and does not accept advertising or funding unrelated to subscriptions. The opinions in such podcasts are entirely those of the discussants, and these discussants are authors and editors for UpToDate. View the UpToDate conflict of interest policy.

This is the complete archive for the UpToDate Clinical Talk Podcasts.

Overdiagnosis of breast cancer with mammography

Date Released: Jan 12 2017

This episode features Dr. Joann Elmore, discussing the UpToDate What’s New topic on the overdiagnosis of breast cancer with mammography. Dr. Sandy Falk hosts.

Dr. ElmoreDr. Joann Elmore is a Professor of Medicine at the University of Washington School of Medicine.

Segment on overdiagnosis of breast cancer with mammography (Dr. Elmore):

  1. Welch HG, Prorok PC, O'Malley AJ, Kramer BS. Breast-Cancer Tumor Size, Overdiagnosis, and Mammography Screening Effectiveness. N Engl J Med 2016; 375:1438.


Joann G Elmore, MD, MPH Nothing to disclose


Glucocorticoids and sepsis; HPV vaccination in young adolescents

Date Released: Dec 21 2016

This episode features Dr. Scott Manaker, discussing the UpToDate What’s New topic on the lack of benefit of glucocorticoids in severe sepsis (starts at 01:07); and Dr. Joel Palefsky, discussing the UpToDate Practice Changing UpDate regarding updated guidelines for HPV vaccination in young adolescents (starts at 14:56). Dr. Sandy Falk hosts.

Listen to the full podcast by pressing the Play Button below, or jump to the segment on glucocorticoids and sepsis, or the segment on HPV vaccination in young adolescents.

Dr. ManakerDr. Scott Manaker is Professor of Medicine at the University of Pennsylvania School of Medicine and an actively practicing physician in pulmonary and critical care medicine.
Dr. PalefskyDr. Joel Palefsky is a Professor of Medicine and an Infectious Disease Specialist at the University of California San Francisco, and the chair of the HPV working group of the National Cancer Institute, AIDS Malignancy Consortia.

Segment on glucocorticoids and sepsis (Dr. Manaker):

  1. Keh D, Trips E, Marx G, et al. Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial. JAMA 2016; 316:1775.

HPV vaccination in young adolescents (Dr. Palefsky):

  1. CDC recommends only two HPV shots for younger adolescents, October 19, 2016. (Accessed on October 22, 2016).


Scott Manaker, MD, PhD Consultant/Advisory boards: Expert witness in workers' compensation and in medical negligence matters [General pulmonary and critical care medicine]. Equity Ownership/Stock Options (Spouse): Johnson & Johnson; Pfizer (Numerous medications and devices). Other Financial Interest: Director of ACCP Enterprises, a wholly owned for-profit subsidiary of ACCP [General pulmonary and critical care medicine (Providing pulmonary and critical care medicine education to non-members of ACCP)].

Joel M Palefsky, MD Grant/Research/Clinical Trial Support: Merck and Co [HPV vaccine (Gardasil-9)]. Consultant/Advisory Boards: TheVax [HPV infection (therapeutic HPV vaccine)]; Ubiome [HPV diagnostics (none)]. Equity Ownership/Stock Options: Antiva Therapeutics [HPV therapeutics (none)]; Agenovir Corporation HPV therapeutics (none)].


Influenza vaccination in pregnancy; Degenerative meniscal tears

Date Released: Dec 7 2016

This episode features Dr. Sonja Rasmussen, discussing infant protection against influenza illness through maternal immunization (starts at 00:44); and Dr. Karl Fields, discussing outcomes for patients with degenerative meniscal tears, comparing meniscectomy with physical therapy (starts at 13:38). Dr. Nancy Sokol hosts.

Listen to the full podcast by pressing the Play Button below, or jump to the segment on influenza and pregnancy or the segment on degenerative meniscal tears.

Dr. RasmussenDr. Sonja Rasmussen is the Director of the Division of Public Health Information Dissemination at the Centers for Disease Control and Prevention, and Editor in Chief of CDC's Morbidity and Mortality Weekly Report, MMWR.
Dr. FieldsDr. Karl Fields is Professor of Family Medicine at the University of North Carolina Medical School in Chapel Hill and is Past President of the American Medical Society of Sports Medicine.

Segment on influenza and pregnancy (Dr. Rasmussen):

  1. Nunes MC, Cutland CL, Jones S, et al. Duration of Infant Protection Against Influenza Illness Conferred by Maternal Immunization: Secondary Analysis of a Randomized Clinical Trial. JAMA Pediatr 2016; 170:840.

Segment on degenerative meniscal tears (Dr. Fields):

  1. Kise NJ, Risberg MA, Stensrud S, et al. Exercise therapy versus arthroscopic partial meniscectomy for degenerative meniscal tear in middle aged patients: randomised controlled trial with two year follow-up. BMJ 2016; 354:i3740.


Sonja A Rasmussen, MD, MS Nothing to disclose

Karl B Fields, MD Nothing to disclose


Evidence-Based Medicine and UpToDate

Date Released: Nov 23 2016

This episode features Dr. Gordon Guyatt, discussing general principles of evidence-based medicine (EBM) and how EBM is incorporated into UpToDate topics, using an example from a topic in UpToDate on aspirin for primary prevention.

Visit for more information on grading recommendations in UpToDate.

Dr. GuyattDr. Gordon Guyatt is Distinguished University Professor in the Departments of Clinical Epidemiology & Biostatistics and Medicine at McMaster University in Hamilton, Ontario, cofounder of the GRADE working group, and co-editor of the Users’ Guides to the Medical Literature.

Gordon Guyatt, MD Nothing to disclose