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Withdrawal syndromes with antihypertensive therapy

Norman M Kaplan, MD
Section Editor
George L Bakris, MD
Deputy Editor
John P Forman, MD, MSc


Abrupt discontinuation of successful antihypertensive therapy can result in one of the following:

Relatively rapid, asymptomatic return of the blood pressure (BP) to pretreatment levels

Slower, asymptomatic return of BP to pretreatment levels

Rebound of the BP with symptoms and signs of sympathetic overactivity (a withdrawal syndrome)

Overshoot of the BP above pretreatment levels

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Literature review current through: Nov 2017. | This topic last updated: Mar 21, 2016.
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