Verapamil and norverapamil in plasma and breast milk during breast feeding

Eur J Clin Pharmacol. 1987;31(5):625-7. doi: 10.1007/BF00606644.

Abstract

The concentrations of verapamil and norverapamil have been measured in milk and plasma samples from a 32 year-old woman treated with verapamil 80 mg tds while breast-feeding her child. The average steady-state concentrations of verapamil and noverapamil in milk were, respectively, 60% and 16% of the concentrations in plasma. The breast-fed child received less than 0.01% of the dose of verapamil given to the mother. No verapamil or norverapamil (less than 1 ng/ml) could be detected in the plasma from the child.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Breast Feeding*
  • Female
  • Humans
  • Hypertension / drug therapy
  • Hypertension / metabolism
  • Infant
  • Infant Nutritional Physiological Phenomena
  • Metabolic Clearance Rate
  • Milk, Human / analysis*
  • Verapamil / analogs & derivatives*
  • Verapamil / blood
  • Verapamil / metabolism*
  • Verapamil / therapeutic use

Substances

  • norverapamil
  • Verapamil