UVB therapy (broadband and narrowband)
- Herbert Hönigsmann, MD
Herbert Hönigsmann, MD
- Professor of Dermatology, Emeritus Chairman
- Medical University of Vienna
Broadband ultraviolet B (UVB) radiation (280 to 320 nm), with or without topical tar, has been used for the treatment of moderate to severe psoriasis for decades. In the early 1980s, the observation that wavelengths around 311 nm were more effective than broad-spectrum UVB in clearing psoriasis led to a major advancement in phototherapy with the development of fluorescent lamps emitting selective UVB spectra in the range of 311 to 313 nm (narrowband UVB) [1,2].
Narrowband UVB has since become the type of phototherapy most frequently used for the treatment of psoriasis and a wide range of skin diseases, including atopic dermatitis, vitiligo, early stages of mycosis fungoides, and pruritic disorders (table 1) [3-5].
This topic will discuss the mechanism of action, treatment protocols, indications, and adverse effects of UVB therapy. PUVA therapy, UVA-1 therapy, and targeted phototherapy are discussed separately. The use of UVB for the treatment of specific skin conditions are discussed in the dedicated topics.
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- PRINCIPLES AND MECHANISMS
- Effects on DNA
- Effects on the immune system
- DEVICES FOR BROADBAND AND NARROWBAND UVB
- CLINICAL INDICATIONS FOR UVB THERAPY
- DOSIMETRY AND TREATMENT PROTOCOLS
- Determination of the initial dose
- Treatment initiation, frequency, and dose increments
- Maintenance therapy
- Combination therapies
- TARGETED PHOTOTHERAPY WITH 308 NM DEVICES
- SAFETY MEASURES
- SHORT- AND LONG-TERM ADVERSE EFFECTS
- SUMMARY AND RECOMMENDATIONS