Uterus transplantation for absolute uterine factor infertility: Surgery, immunosuppression, and obstetric management
- Mats Brännström, MD, PhD
Mats Brännström, MD, PhD
- Professor of Obstetrics and Gynecology
- University of Gothenburg, Sweden
- César Díaz-García, MD
César Díaz-García, MD
- Associate Professor of Obstetrics and Gynecology
- La Fe University Hospital, University of Valencia
Uterus transplantation is a highly experimental procedure for the treatment of absolute uterine factor infertility (AUFI). AUFI refers to infertility that is completely attributable to uterine absence (congenital or surgical) or an abnormality (anatomic or functional) that prevents embryo implantation or completion of pregnancy to term. This topic will review the surgeries for the donor and recipient, immunosuppression, and obstetric issues involved in uterus transplantation. The intent of this topic is to provide an overview of the critical issues for clinicians and patients; the topic is based on the experience of the authors and should not be used for treatment decisions.
Related discussions on the ethical issues, patient selection, and consent involved in uterus transplantation, as well as topics on solid organ transplantation, are presented separately.
●(See "Transplantation immunobiology".)
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- INDICATIONS, ETHICS, AND PATIENT SELECTION
- Uterus removal
- - Living donor
- - Deceased donor
- Uterus transplantation
- - Procedure
- - Complications
- GRAFT COMPLICATIONS
- Unplanned graft removal
- Our approach
- Treatment risks
- Use in pregnancy
- OBSTETRIC ISSUES
- Impact of immunosuppressive agents
- Obstetric complications
- PLANNED GRAFT REMOVAL
- SUMMARY AND RECOMMENDATIONS