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Tumor necrosis factor-alpha inhibitors: An overview of adverse effects

Bruce Kirkham, BA, MD, FRCP, FRACP
Section Editor
Daniel E Furst, MD
Deputy Editor
Paul L Romain, MD


Inhibitors of tumor necrosis factor (TNF)-alpha represent important treatment advances in a number of inflammatory conditions, including rheumatoid arthritis (RA), the seronegative spondyloarthropathies, and inflammatory bowel disease (IBD). TNF-alpha inhibitors offer a targeted strategy that contrasts with the nonspecific immunosuppressive agents traditionally used to treat most inflammatory diseases. However, multiple adverse effects of TNF-alpha inhibition have been identified through both clinical trials and post-marketing surveillance. These include:

Injection site reactions

Infusion reactions



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Literature review current through: Nov 2017. | This topic last updated: Sep 12, 2016.
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