Abstract
We report a patient with AIDS who had an anaphylactic-like reaction from trimethoprim-sulfamethoxazole. Clinical suspicion of anaphylaxis should be considered in patients presenting with fever, hypotension, eosinophilia, rash, flushing or pulmonary infiltrates after initial exposure and re-exposure to the medication. This case highlights the need for healthcare professionals to be reminded of the association between this unusual antibiotic reaction resembling sepsis and HIV disease.
Keywords:
AIDS; HIV; Trimethoprim-sulfamethoxazole; adverse drug reaction; anaphylaxis; sepsis.
© The Author(s) 2015.
MeSH terms
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AIDS-Related Opportunistic Infections / prevention & control*
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Acquired Immunodeficiency Syndrome / complications*
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Acquired Immunodeficiency Syndrome / diagnosis
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Adult
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Anaphylaxis*
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / therapeutic use
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Drug Hypersensitivity
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Female
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Fever / etiology
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Humans
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Pneumonia, Pneumocystis / drug therapy
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Pneumonia, Pneumocystis / prevention & control*
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Transgender Persons
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Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage*
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Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Substances
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Anti-Bacterial Agents
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Trimethoprim, Sulfamethoxazole Drug Combination