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Treatment protocols for anal cancer

Tim Brenner, PharmD, BCOP
Shrina Duggal, PharmD, BCOP
Jim Natale, PharmD, BCOP
Scott M Wirth, PharmD, BCOP
Section Editor
John W Mucenski, PharmD
Deputy Editor
Diane MF Savarese, MD


The following material represents a subset of chemotherapy regimens that are used for the treatment of patients with anal cancer, both for primary treatment of locoregional disease, and for treatment of advanced disease. This is not an exhaustive list; it includes regimens that are considered by the authors and editors to be commonly used and important for the care of patients with anal cancer. Additional regimens may be added over time, particularly as treatment for anal cancer evolves.

This topic review is intended to provide only a listing of chemotherapy regimens. It does not address the appropriate context for use of these regimens in the care of patients with anal. Clinicians should refer to the individual disease-oriented topic review that discusses the use of these protocols in appropriate clinical situations. (See "Clinical features, staging, and treatment of anal cancer".)

These tables are provided as examples of how to administer these regimens; there may be other acceptable methods. All chemotherapy regimens must be administered by clinicians who are trained in the use of chemotherapy. The clinician is expected to use his or her independent medical judgment in the context of individual circumstances to make adjustments, as necessary.


Initial therapy for locoregional disease

Mitomycin plus fluorouracil and RT — (table 1)

Mitomycin plus capecitabine and RT — (table 2)

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Literature review current through: Nov 2017. | This topic last updated: Sep 16, 2016.
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