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Medline ® Abstract for Reference 62

of 'Treatment of early stage (IA to IIA) mycosis fungoides'

Treatment of patch and plaque stage mycosis fungoides with imiquimod 5% cream.
Deeths MJ, Chapman JT, Dellavalle RP, Zeng C, Aeling JL
J Am Acad Dermatol. 2005;52(2):275.
BACKGROUND: Systemic interferon is effective in the treatment of mycosis fungoides (MF). Imiquimod is effective in the treatment of some epidermal neoplasms and induces localized interferon production.
OBJECTIVE: To evaluate the safety and efficacy of topical imiquimod 5% cream for the treatment of patch and plaque stage MF.
METHODS: Six patients with stage IA to IIB MF were treated with topical imiquimod 5% cream 3 times per week for 12 weeks in this open label pilot study. Index lesions were biopsied pre- and post- treatment, and up to 4 additional treated lesions were monitored for 16 weeks.
RESULTS: Three of 6 patients had histologic clearance of disease in index lesions, and also demonstrated significant improvement in the clinical scores for all treated lesions. A fourth patient had 2 of 4 lesions respond clinically. Application site reactions were limited to those patients responding to treatment.
CONCLUSION: In this preliminary open label study topical imiquimod 5% cream was well tolerated and associated with a histologic and clinical response rate of 50%.
Department of Dermatology, University of Colorado Health Sciences Center, Denver, Colorado 80045-0510, USA.