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Medline ® Abstract for Reference 15

of 'Treatment of early stage (IA to IIA) mycosis fungoides'

Topical carmustine (BCNU) for cutaneous T cell lymphoma: a 15-year experience in 143 patients.
Zackheim HS, Epstein EH Jr, Crain WR
J Am Acad Dermatol. 1990;22(5 Pt 1):802.
One hundred forty-three patients with cutaneous T cell lymphoma were treated with topical carmustine (BCNU). A complete response was obtained in 86% of those with limited extent (less than 10%) plaques (T1 stage), in 48% of those with extensive (greater than or equal to 10%) plaques (T2 stage), and in 21% of those with erythroderma. The median time to achieve complete response was 11.5 weeks. Favorable results were obtained in patients with less than 5% involvement treated locally. Mild hematopoietic depression occurred in less than 10% of patients. Erythematous reactions were common, but no secondary cutaneous malignancies occurred. Differences in freedom from relapse or in survival between T2-stage patients with and those without clinical adenopathy were not statistically significant. The 5-year overall survival rate was 77%; the median survival time was 9.4 years.
Department of Dermatology, University of California, San Francisco.