Transfusion-transmitted bacterial infection
- Denis Spelman, MBBS, FRACP, FRCPA, MPH
Denis Spelman, MBBS, FRACP, FRCPA, MPH
- Adjunct Professor, Monash University
- Alfred Hospital, Victoria, Australia
- Graeme MacLaren, MBBS, FCICM, FRACP, FCCP, FCCM
Graeme MacLaren, MBBS, FCICM, FRACP, FCCP, FCCM
- National University Hospital, Singapore
- The Royal Children's Hospital, Melbourne, Australia
Transfusion-transmitted bacterial infection (TTBI) is an important complication of blood product administration [1-3]. The incidence of TTBI is higher than the incidence of transfusion-transmitted viral infection [4-6].
Issues related to TTBI will be reviewed here. Issues related to laboratory testing of donated blood for infectious agents are discussed separately. (See "Blood donor screening: Laboratory testing".)
There is no consensus definition for transfusion-transmitted bacterial infection [1-3]:
●One paper published by a French group separated reports into definite, probable, and possible cases . In "definite" cases, the same bacteria were isolated from both the blood product and the transfusion recipient. In "probable" cases, bacteria were isolated from the blood product, but the recipient's blood was either not cultured or was culture negative. In "possible" cases, no bacteria were isolated from the blood product (either because culture was not performed or was negative) and the blood culture from the recipient was positive with no other apparent source.
●A British group defined transfusion-transmitted bacterial infection as bacterial infection following transfusion (in the absence of infection prior to transfusion), with evidence of blood product contamination or infection in the donor .
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