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Syphilis in the HIV-infected patient

Anne Rompalo, MD
Section Editor
Noreen A Hynes, MD, MPH, DTM&H
Deputy Editor
Jennifer Mitty, MD, MPH


Syphilis is a sexually acquired infection, which, if left untreated, is characterized by episodes of active clinical disease interrupted by periods of latent (asymptomatic) infection. Some studies suggest that HIV infection may modulate the clinical presentation of syphilis (eg, greater organ involvement, atypical and florid skin rashes, more rapid progression to neurosyphilis), as well as the clinical and serologic response to syphilis treatment. Syphilis may also have a negative impact on the HIV viral load.

This topic will review the epidemiology, clinical presentation, diagnosis, and treatment of syphilis in HIV-infected patients. Other topic reviews that discuss syphilis include:

(See "Syphilis: Epidemiology, pathophysiology, and clinical manifestations in HIV-uninfected patients".)

(See "Syphilis: Treatment and monitoring".)

(See "Syphilis: Screening and diagnostic testing".)

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Literature review current through: Nov 2017. | This topic last updated: Sep 06, 2017.
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