Suspected Staphylococcus aureus and streptococcal skin and soft tissue infections in neonates: Evaluation and management
- Sheldon L Kaplan, MD
Sheldon L Kaplan, MD
- Editor-in-Chief — Pediatrics
- Section Editor — Pediatric Infectious Diseases
- Professor and Vice Chairman for Clinical Affairs
- Baylor College of Medicine
The evaluation and management of suspected Staphylococcus aureus or streptococcal skin and soft tissue infections (SSTIs) in neonates (≤28 days of age) are discussed here. Clinical features of SSTI; the evaluation and management of staphylococcal and streptococcal SSTIs in children older than 28 days; the epidemiology, prevention, and control of methicillin-resistant S. aureus (MRSA) infections in children; and the treatment of invasive MRSA infections in children are discussed separately.
- Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 2011; 52:e18.
- American Academy of Pediatrics. Staphylococcal infections. In: Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed, Kimberlin DW, Brady MT, Jackson MA, Long SS (Eds), American Academy of Pediatrics, 2015. p.715.
- Fortunov RM, Hulten KG, Hammerman WA, et al. Evaluation and treatment of community-acquired Staphylococcus aureus infections in term and late-preterm previously healthy neonates. Pediatrics 2007; 120:937.
- Miller LG, Perdreau-Remington F, Bayer AS, et al. Clinical and epidemiologic characteristics cannot distinguish community-associated methicillin-resistant Staphylococcus aureus infection from methicillin-susceptible S. aureus infection: a prospective investigation. Clin Infect Dis 2007; 44:471.
- Day CT, Kaplan SL, Mason EO, Hulten KG. Community-associated Staphylococcus aureus infections in otherwise healthy infants less than 60 days old. Pediatr Infect Dis J 2014; 33:98.
- Autret E, Laugier J, Marimbu J, et al. [Comparison of plasma levels of amoxicillin administered by oral and intravenous routes in neonatal bacterial colonization]. Arch Fr Pediatr 1988; 45:679.
- Boothman R, Kerr MM, Marshall MJ, Burland WL. Absorption and excretion of cephalexin by the newborn infant. Arch Dis Child 1973; 48:147.
- Gorwitz RJ. A review of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections. Pediatr Infect Dis J 2008; 27:1.
- History and examination
- Laboratory evaluation
- MANAGEMENT APPROACH
- Localized pustulosis
- SSTI more severe than localized pustulosis
- ANTIMICROBIAL THERAPY
- Choice of initial therapy
- - SSTI without systemic findings
- - SSTI with systemic findings
- Duration of therapy
- RESPONSE TO THERAPY
- Monitoring response
- Failure to respond
- SOCIETY GUIDELINE LINKS
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS