Peyronie's disease: a review

J Urol. 2003 Apr;169(4):1234-41. doi: 10.1097/01.ju.0000053800.62741.fe.

Abstract

Purpose: We provide a current review of Peyronie's disease.

Materials and methods: We reviewed the world peer reviewed literature on the pathology, pathogenesis, diagnosis and treatment of Peyronie's disease.

Results: The incidence of Peyronie's disease has continuously increased during the last 30 years. However, fewer patients need prosthesis surgery as the sole treatment option because of earlier diagnosis, improved medical therapy, refinement in surgical technique and better understanding of the basic sciences of the disease.

Conclusions: Currently patients with Peyronie's disease have had improvements in prognosis and experienced an expansion of the available therapeutic options.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Differentiation / genetics
  • Cell Division / genetics
  • Fibroblasts / pathology
  • Gene Expression Regulation / physiology
  • Humans
  • Male
  • Myostatin
  • Oligonucleotide Array Sequence Analysis
  • Penile Induration / genetics*
  • Penile Induration / pathology
  • Penile Induration / therapy
  • Penis / pathology
  • Reactive Oxygen Species / metabolism
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta1

Substances

  • MSTN protein, human
  • Myostatin
  • Reactive Oxygen Species
  • TGFB1 protein, human
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1