Thyroid imaging has historically relied heavily on scintigraphy, although, not surprisingly in view of the superficial position of the gland, ultrasound has assumed an increasingly prominent role in recent years. The other cross-sectional imaging modalities can also be useful, and the emergence of new radiopharmaceuticals and the increasingly central role of fine needle aspiration cytology have further added to the range of diagnostic techniques available. This review attempts to summarize the current state of knowledge, and makes some suggestions for the most efficient use of imaging resources in the investigation of thyroid disease.