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Medline ® Abstract for Reference 55

of 'Supportive care of the patient with locally advanced or metastatic exocrine pancreatic cancer'

Venous thromboembolism and prognosis in cancer.
Khorana AA
Thromb Res. 2010 Jun;125(6):490-3. Epub 2010 Jan 25.
Venous thromboembolism (VTE) is a frequent complication of malignancy, and its incidence has increased markedly in recent years. VTE itself can directly lead to patient mortality, and is the second leading cause of death in patients with cancer. Furthermore, emerging data suggest that activation of coagulation in malignancy is integrally linked with tumor biology, particularly with angiogenesis. The development of the clinical hypercoagulable state is also linked with adverse prognosis in patients with cancer, including patients receiving systemic chemotherapy. This review focuses on the clinical evidence documenting a link between VTE and adverse short-term and long-term prognosis in patients with cancer.
James P. Wilmot Cancer Center, and the Department of Medicine, University of Rochester, Rochester, NY 14642, USA. alok_khorana@URMC.rochester.edu