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Medline ® Abstract for Reference 29

of 'Supportive care of the patient with locally advanced or metastatic exocrine pancreatic cancer'

Malignant distal biliary obstruction: a systematic review and meta-analysis of endoscopic and surgical bypass results.
Moss AC, Morris E, Leyden J, MacMathuna P
Cancer Treat Rev. 2007;33(2):213.
BACKGROUND: Surgical bypass and endoscopic stents are available for palliative bypass of malignant distal biliary obstruction.
AIM: Comparison of reported outcomes in randomized controlled trials (RCTs) which included surgery, endoscopic plastic stents or endoscopic metal stents in palliative relief of malignant distal biliary obstruction.
METHODS: Systematic review and meta-analysis of published literature and conference proceedings review to June 2006.
RESULTS: We found 24 studies, containing 2436 patients, which met our inclusion criteria. Endoscopic stenting with plastic stents (three studies) is associated with a lower risk of complications (RR 0.60, 95% CI 0.45-0.81), but a higher risk of recurrent biliary obstruction (RR 18.59, 95% CI 5.33 -64.86) than traditional surgical bypass. Self-expanding metal stents (seven studies) are associated with a significantly reduced risk of recurrent biliary obstruction at4 months (RR 0.44, 95% CI 0.3, 0.63), or prior to death or end of study (RR 0.52, 95% CI 0.39-0.69), but are not superior to plastic stents in terms of technical success, therapeutic success, mortality or complications. Cost-effectiveness outcomes were not suitable for meta-analysis. No other plastic stent designs have been demonstrated to be superior to polyethylene stents (12 studies).
CONCLUSIONS: Endoscopic metal stents are the intervention of choice in patients with malignant distal biliary obstruction, producing similar outcomes to plastic stents, but with improved patency rates.
Gastrointestinal Unit, Mater Misericordiae University Hospital, Eccles Street, Dublin 1, Ireland. amoss@bidmc.harvard.edu<amoss@bidmc.harvard.edu>