A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib

J Natl Cancer Inst. 2008 Feb 20;100(4):282-4. doi: 10.1093/jnci/djm311. Epub 2008 Feb 12.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Benzenesulfonates / adverse effects*
  • Humans
  • Hypertension / chemically induced*
  • Hypertension / metabolism
  • Indoles / adverse effects*
  • Niacinamide / analogs & derivatives
  • Phenylurea Compounds
  • Protein Kinase Inhibitors / adverse effects*
  • Proteinuria / chemically induced*
  • Proteinuria / metabolism
  • Pyridines / adverse effects*
  • Pyrroles / adverse effects*
  • Receptors, Vascular Endothelial Growth Factor / drug effects*
  • Signal Transduction / drug effects
  • Sorafenib
  • Sunitinib

Substances

  • Antineoplastic Agents
  • Benzenesulfonates
  • Indoles
  • Phenylurea Compounds
  • Protein Kinase Inhibitors
  • Pyridines
  • Pyrroles
  • Niacinamide
  • Sorafenib
  • Receptors, Vascular Endothelial Growth Factor
  • Sunitinib