Sulfasalazine induced immune thrombocytopenia in a patient with rheumatoid arthritis

Clin Rheumatol. 2017 Feb;36(2):477-479. doi: 10.1007/s10067-016-3420-9. Epub 2016 Oct 24.

Abstract

Sulfasalazine has long been used for the treatment of rheumatoid arthritis and is often chosen as a first-line treatment. Here, we report a case of sulfasalazine-induced autoimmune thrombocytopenia and review the mechanisms behind drug-induced immune thrombocytopenia (DITP) and the approach to its diagnosis and management.

Keywords: Autoantibodies; Blood platelets disorders; Hematologic diseases; Rheumatic diseases; Rheumatoid arthritis (RA); Thrombocytopenia; Tissues or models.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / drug therapy*
  • Blood Platelets / drug effects
  • Humans
  • Male
  • Purpura, Thrombocytopenic, Idiopathic / chemically induced*
  • Purpura, Thrombocytopenic, Idiopathic / complications
  • Remission Induction
  • Sulfasalazine / adverse effects*
  • Sulfasalazine / therapeutic use
  • Treatment Outcome

Substances

  • Sulfasalazine