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Staphylococcus aureus bacteremia in children: Management and outcome

Author
Sheldon L Kaplan, MD
Section Editor
Morven S Edwards, MD
Deputy Editor
Carrie Armsby, MD, MPH

INTRODUCTION

Staphylococcus aureus is a leading cause of both community- and hospital-associated bacteremia. S. aureus bacteremia (SAB) is associated with increased morbidity and mortality, even with appropriate therapy.

The treatment and outcome of S. aureus bacteremia in children are reviewed here. The epidemiology and clinical manifestations of S. aureus bacteremia in children are discussed separately. (See "Staphylococcus aureus bacteremia in children: Epidemiology and clinical features".)

MANAGEMENT

Supportive care — Supportive measures for children with S. aureus bacteremia (SAB) may include:

Fever management

Respiratory support for patients with pneumonia or respiratory distress (see "Acute respiratory distress in children: Emergency evaluation and initial stabilization", section on 'Initial stabilization' and "Pneumonia in children: Inpatient treatment", section on 'Respiratory support')

                 

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Literature review current through: Jul 2017. | This topic last updated: May 11, 2017.
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References
Top
  1. Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 2011; 52:e18.
  2. Spencer DH, Sellenriek P, Burnham CA. Validation and implementation of the GeneXpert MRSA/SA blood culture assay in a pediatric setting. Am J Clin Pathol 2011; 136:690.
  3. Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 49:1.
  4. Rubin LG, Shih S, Shende A, et al. Cure of implantable venous port-associated bloodstream infections in pediatric hematology-oncology patients without catheter removal. Clin Infect Dis 1999; 29:102.
  5. Adler A, Yaniv I, Solter E, et al. Catheter-associated bloodstream infections in pediatric hematology-oncology patients: factors associated with catheter removal and recurrence. J Pediatr Hematol Oncol 2006; 28:23.
  6. Celebi S, Sezgin ME, Cakır D, et al. Catheter-associated bloodstream infections in pediatric hematology-oncology patients. Pediatr Hematol Oncol 2013; 30:187.
  7. American Academy of Pediatrics. Staphylococcal infections. In: Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed, Kimberlin DW, Brady MT, Jackson MA, Long SS (Eds), American Academy of Pediatrics, 2015. p.715.
  8. Carrillo-Marquez MA, Hulten KG, Mason EO, Kaplan SL. Clinical and molecular epidemiology of Staphylococcus aureus catheter-related bacteremia in children. Pediatr Infect Dis J 2010; 29:410.
  9. Rybak MJ, Lomaestro BM, Rotschafer JC, et al. Therapeutic monitoring of vancomycin in adults summary of consensus recommendations from the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Pharmacotherapy 2009; 29:1275.
  10. Suryati BA, Watson M. Staphylococcus aureus bacteraemia in children: a 5-year retrospective review. J Paediatr Child Health 2002; 38:290.
  11. Adem PV, Montgomery CP, Husain AN, et al. Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children. N Engl J Med 2005; 353:1245.
  12. Gonzalez BE, Martinez-Aguilar G, Hulten KG, et al. Severe Staphylococcal sepsis in adolescents in the era of community-acquired methicillin-resistant Staphylococcus aureus. Pediatrics 2005; 115:642.
  13. Skinner, D, Keefer, CS. Significance of bacteremia caused by Staphylococcus aureus: A study of one hundred and twenty-two cases and a review of the literature concerned with experimental infection in animals. Arch Intern Med 1941; 68:851.
  14. Watson RS, Carcillo JA, Linde-Zwirble WT, et al. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med 2003; 167:695.
  15. Frederiksen MS, Espersen F, Frimodt-Møller N, et al. Changing epidemiology of pediatric Staphylococcus aureus bacteremia in Denmark from 1971 through 2000. Pediatr Infect Dis J 2007; 26:398.
  16. Asgeirsson H, Gudlaugsson O, Kristinsson KG, et al. Low mortality of Staphylococcus aureus bacteremia in Icelandic children: nationwide study on incidence and outcome. Pediatr Infect Dis J 2015; 34:140.
  17. Cobos-Carrascosa E, Soler-Palacín P, Nieves Larrosa M, et al. Staphylococcus aureus Bacteremia in Children: Changes During Eighteen Years. Pediatr Infect Dis J 2015; 34:1329.
  18. Valente AM, Jain R, Scheurer M, et al. Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia. Pediatrics 2005; 115:e15.
  19. Welsh KJ, Abbott AN, Lewis EM, et al. Clinical characteristics, outcomes, and microbiologic features associated with methicillin-resistant Staphylococcus aureus bacteremia in pediatric patients treated with vancomycin. J Clin Microbiol 2010; 48:894.
  20. Hill PC, Wong CG, Voss LM, et al. Prospective study of 125 cases of Staphylococcus aureus bacteremia in children in New Zealand. Pediatr Infect Dis J 2001; 20:868.
  21. Friedland IR, du Plessis J, Cilliers A. Cardiac complications in children with Staphylococcus aureus bacteremia. J Pediatr 1995; 127:746.
  22. McNeil JC, Ligon JA, Hulten KG, et al. Staphylococcus aureus Infections in Children With Congenital Heart Disease. J Pediatric Infect Dis Soc 2013; 2:337.