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Spontaneous intracerebral hemorrhage: Pathogenesis, clinical features, and diagnosis

Guy Rordorf, MD
Colin McDonald, MD
Section Editor
Scott E Kasner, MD
Deputy Editor
Janet L Wilterdink, MD


Intracerebral hemorrhage (ICH) is the second most common cause of stroke, trailing only ischemic stroke in frequency [1,2]. Estimates of the annual incidence range from 16 to 33 cases per 100,000 [3]. There are many underlying pathological conditions associated with ICH; hypertension, amyloid angiopathy, ruptured saccular aneurysm, and vascular malformation account for the majority of cases.

The pathogenesis, epidemiology, clinical features, and diagnosis of ICH will be reviewed here, with an emphasis upon hypertensive hemorrhage. The prognosis and treatment of ICH are discussed separately. (See "Spontaneous intracerebral hemorrhage: Treatment and prognosis".)


Etiologies — Causes of nontraumatic ICH include [4-6]:


Cerebral amyloid angiopathy

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Literature review current through: Nov 2017. | This topic last updated: Dec 04, 2013.
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