Sclerotherapy of varicose and telangiectatic leg veins. Minimal sclerosant concentration of hypertonic saline and its relationship to vessel diameter

J Dermatol Surg Oncol. 1991 Jan;17(1):65-70. doi: 10.1111/j.1524-4725.1991.tb01595.x.

Abstract

The author reports the results of a double-blind, paired-comparison study using saline sclerosant plus or minus heparin additive. The study was designed to elucidate the effects of increasing concentrations of hypertonic saline with regard to vessel diameter, clinical efficacy, complications, and discomfort. Six hundred women with bilaterally symmetrical starburst telangiectasias or varicose veins were entered into the study. Sodium chloride 11.7% appeared to be the minimal sclerosant concentration of saline that produced the most effective vein sclerosis of vessels of less than 8 mm in diameter, while producing the least morbidity. The optimal concentration of the sclerosant may vary with the diameter of the vessels under therapeutic consideration.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Bandages
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Heparin / administration & dosage
  • Heparin / therapeutic use
  • Humans
  • Leg / blood supply*
  • Middle Aged
  • Saline Solution, Hypertonic / administration & dosage
  • Saline Solution, Hypertonic / adverse effects
  • Saline Solution, Hypertonic / therapeutic use*
  • Sclerosing Solutions / administration & dosage
  • Sclerosing Solutions / adverse effects
  • Sclerosing Solutions / therapeutic use*
  • Sclerotherapy / adverse effects
  • Sclerotherapy / methods*
  • Telangiectasis / pathology
  • Telangiectasis / therapy*
  • Thrombophlebitis / etiology
  • Thrombosis / etiology
  • Time Factors
  • Varicose Veins / pathology
  • Varicose Veins / therapy*
  • Veins / pathology

Substances

  • Saline Solution, Hypertonic
  • Sclerosing Solutions
  • Heparin