Medline ® Abstract for Reference 34
of 'Sleep-wake disturbances and sleep disorders in patients with dementia'
REM latency in Alzheimer's disease.
Bliwise DL, Tinklenberg J, Yesavage JA, Davies H, Pursley AM, Petta DE, Widrow L, Guilleminault C, Zarcone VP, Dement WC
Biol Psychiatry. 1989 Feb;25(3):320-8.
Latency to the first episode of rapid eye movement sleep (REML) has been proposed as a potential biomarker for Alzheimer's disease (AD). In this study, we compared REML values from 28 AD patients and 28 age- and sex-matched controls. We employed multiple definitions of REML and multiple cutoffs to classify patients and controls. Results indicated that the best REML definition and optimal cutoff criterion resulted in only 65% correct classifications. We discuss the longer REML in AD patients relative to controls in terms of both overall sleep disturbance and selective deterioration of the REM-cholinergic system. As REML may be relatively short in other forms of psychopathology (e.g., affective disorders), REML may still hold promise in the differential diagnosis of dementia and pseudodementia.
Department of Psychiatry and Behavioral Sciences, Stanford Medical School, CA 94305.