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Medline ® Abstract for Reference 21

of 'Sleep-wake disturbances and sleep disorders in patients with dementia'

The Relationship between Sleep Quality and Brain Amyloid Burden.
Brown BM, Rainey-Smith SR, Villemagne VL, Weinborn M, Bucks RS, Sohrabi HR, Laws SM, Taddei K, Macaulay SL, Ames D, Fowler C, Maruff P, Masters CL, Rowe CC, Martins RN, AIBL Research Group
Sleep. 2016;39(5):1063. Epub 2016 May 1.
STUDY OBJECTIVES: To evaluate the association between self-reported sleep quality and levels of brainβ-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE)ε4 allele on any associations found.
METHODS: This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβpositron emission tomography imaging for the quantification of brain Aβburden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβburden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOEε4 carriage entered as a moderator.
RESULTS: Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ(B = 0.003 [standard error = 0.001], P = 0.02). APOEε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβburden.
CONCLUSIONS: Our findings suggest a relationship between brain Aβburden and sleep latency, independent of APOEε4 genotype.
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia.