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Medline ® Abstract for Reference 17

of 'Sleep-wake disturbances and sleep disorders in patients with dementia'

Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study.
Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Ensrud KE, Stefanick ML, Laffan A, Stone KL, Osteoporotic Fractures in Men (MrOS) Study Group
Sleep. 2011;34(10):1347. Epub 2011 Oct 1.
STUDY OBJECTIVES: To examine the association of objectively and subjectively measured sleep characteristics with cognition in older men.
DESIGN: A population-based cross-sectional study.
SETTING: 6 centers in the United States.
PARTICIPANTS: 3,132 community-dwelling older men (mean age 76.4±5.6 years).
MEASUREMENTS AND RESULTS: Objectively measured sleep predictors from wrist actigraphy were total sleep time (TST), sleep efficiency (SE), and wake after sleep onset (WASO). Subjective sleep predictors were self-reported poor sleep (Pittsburgh Sleep Quality Index [PSQI]>5), excessive daytime sleepiness (EDS, Epworth Sleepiness Scale Score>10), and TST. Cognitive outcomes were measured with the Modified Mini-Mental State examination (3MS), the Trails B test, and the Digit Vigilance Test (DVT). After adjustment for multiple potential confounders, WASO was modestly related to poorer cognition. Compared to those with WASO<90 min, men with WASO≥90 min took 6.1 sec longer to complete the Trails B test and had a 0.9-point worse 3MS score, on average (P<0.05). Actigraphically measured long sleepers had a slightly worse 3MS score compared to those with 7-8 h of sleep, but had similar Trails B and DVT completion times. Compared to those who self-reported sleeping 7-8 h, long sleepers (>8 h) on average took 8.6 sec more to complete the Trails B test, had a 0.6-point worse 3MS score, and took 46 sec longer to complete the DVT (P<0.05). PSQI and EDS were not independently related to cognitive outcomes.
CONCLUSIONS: There were modest cross-sectional associations of WASO and self-reported long sleep with cognition among older community-dwelling men. EDS and PSQI were not related to cognition.
Research Institute, California Pacific Medical Center, San Francisco, CA 94107, USA. tblackwell@sfcc-cpmc.net