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Sickle cell trait

Elliott P Vichinsky, MD
Section Editor
Donald H Mahoney, Jr, MD
Deputy Editor
Jennifer S Tirnauer, MD


Sickle cell trait is a benign carrier condition, usually with none of the symptoms of sickle cell anemia or other sickle cell diseases. However, knowledge of sickle cell trait is important in many settings such as preconception counseling and evaluation of rare complications. The screening, diagnosis, potential complications, and routine management of individuals with sickle cell trait are discussed here.

Homozygous sickle cell disease and other sickle cell disease variants (eg, sickle cell beta-thalassemia, hemoglobin SC disease) are discussed in detail separately.

(See "Overview of the clinical manifestations of sickle cell disease".)

(See "Diagnosis of sickle cell disorders".)

(See "Overview of the management and prognosis of sickle cell disease".)

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Literature review current through: Dec 2017. | This topic last updated: Jan 09, 2018.
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