- Patricia Tai, MB, BS, DABR, FRCR, FRCPC
Patricia Tai, MB, BS, DABR, FRCR, FRCPC
- Clinical Oncologist
- Clinical Professor
- University of Saskatchewan
- Canada Department of Radiation Oncology
- Allan Blair Cancer Center
- Section Editors
- Robert S Stern, MD
Robert S Stern, MD
- Section Editor — Nonmelanoma Skin Cancer
- Professor of Dermatology
- Harvard Medical School
- June K Robinson, MD
June K Robinson, MD
- Section Editor — Nonmelanoma Skin Cancer
- Professor of Clinical Dermatology
- Northwestern University Feinberg School of Medicine
Sebaceous carcinoma is a rare malignant tumor of the sebaceous glands . It can occur in any body site where sebaceous glands are present, but is most commonly found in the head and neck region, particularly in the periocular area . Sebaceous carcinoma of the eyelid (picture 1) may be mistaken for inflammatory lesions, such as chalazion or blepharoconjunctivitis, resulting in a delayed diagnosis and poorer prognosis .
Sebaceous carcinomas can occur sporadically or may be associated with Muir-Torre syndrome, a subset of the hereditary nonpolyposis colorectal cancer syndrome (HNCCS, Lynch syndrome) characterized by single or multiple sebaceous neoplasms, keratoacanthomas, and internal malignancy .
This topic will review the pathogenesis, clinical presentation, diagnosis, and treatment of sebaceous carcinoma. Muir-Torre syndrome and Lynch syndrome are discussed separately. (See "Muir-Torre syndrome" and "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis" and "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Screening and management".)
Sebaceous carcinoma is a rare tumor, with an estimated incidence rate of approximately 1 to 2 per 1,000,000 per year [2,4,5]. However, sebaceous carcinoma is the most common eyelid malignancy after basal cell carcinoma and squamous cell carcinoma [6,7].
A review of the Surveillance, Epidemiology and End Results (SEER) database from 1973 to 2004 identified 1349 cases of sebaceous carcinoma . More than 90 percent of cases were seen in patients over 50 years old and the median age was 72 years. Sebaceous carcinoma is exceedingly rare in children [8,9].To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- CLINICAL PRESENTATION
- Eyelid sebaceous carcinoma
- Extra-ocular sebaceous carcinoma
- ASSOCIATION WITH MUIR-TORRE SYNDROME
- Screening for DNA mismatch repair defects
- DIFFERENTIAL DIAGNOSIS
- EVALUATION AND STAGING
- Local disease
- - Surgical treatment
- - Radiation therapy
- - Adjuvant therapies
- Metastatic disease
- SUMMARY AND RECOMMENDATIONS