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Medline ® Abstract for Reference 64

of 'Salicylate poisoning in children and adolescents'

Multiple-dose charcoal and whole-bowel irrigation do not increase clearance of absorbed salicylate.
Mayer AL, Sitar DS, Tenenbein M
Arch Intern Med. 1992;152(2):393.
BACKGROUND: This study assesses whether oral multiple-dose charcoal therapy (MDC) or whole-bowel irrigation (WBI) enhances the excretion of previously absorbed salicylate.
METHODS: A controlled, randomized, three-limbed crossover protocol was used in nine humans who ingested aspirin. Salicylate levels were measured in serial serum specimens and 32-hour urine collections and kinetic parameters were calculated.
RESULTS: There were no differences among the control (CTL), MDC, or WBI groups for area under the serum concentration vs time curve (CTL, 2320 +/- 501 mg/L.h MDC, 2040 +/- 454 mg/L.h; WBI, 2093 +/- 418 mg/L.h) or for urinary salicylates (CTL, 54.9% +/- 9.4%; MDC, 50.9% +/- 8.0%, WBI, 52.4% +/- 13.7% of ingested dose).
CONCLUSIONS: Our data do not support the use of either MDC or WBI to enhance the excretion of previously absorbed salicylate in poisoned patients. In patients with drug overdoses, a clear rectal effluent remains as the endpoint for WBI.
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.