Abstract
We report a male infant with congenital tuberculosis who developed cerebral hemorrhage associated with vitamin K deficiency during treatment with isoniazid and rifampin. Despite an absence of risk factors for vitamin K deficiency, the severe hemorrhagic disorder occurred at 4 months of age. We speculate that vitamin K deficiency in the present case may have resulted from a synergic effect of antituberculosis agents and immaturity of vitamin K metabolism and/or its absorption.
MeSH terms
-
Cerebral Hemorrhage / chemically induced*
-
Cerebral Hemorrhage / complications
-
Cerebral Hemorrhage / diet therapy
-
Humans
-
Infant
-
Infectious Disease Transmission, Vertical
-
Isoniazid / adverse effects*
-
Isoniazid / therapeutic use
-
Male
-
Rifampin / adverse effects*
-
Rifampin / therapeutic use
-
Streptomycin / therapeutic use
-
Tuberculosis / complications
-
Tuberculosis / congenital*
-
Tuberculosis / drug therapy*
-
Vitamin K / therapeutic use
-
Vitamin K Deficiency / chemically induced*
-
Vitamin K Deficiency / complications
-
Vitamin K Deficiency / diet therapy
Substances
-
Vitamin K
-
Isoniazid
-
Rifampin
-
Streptomycin