Cerebral hemorrhage associated with vitamin K deficiency in congenital tuberculosis treated with isoniazid and rifampin

Pediatr Infect Dis J. 2002 Nov;21(11):1088-90. doi: 10.1097/00006454-200211000-00029.

Abstract

We report a male infant with congenital tuberculosis who developed cerebral hemorrhage associated with vitamin K deficiency during treatment with isoniazid and rifampin. Despite an absence of risk factors for vitamin K deficiency, the severe hemorrhagic disorder occurred at 4 months of age. We speculate that vitamin K deficiency in the present case may have resulted from a synergic effect of antituberculosis agents and immaturity of vitamin K metabolism and/or its absorption.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Hemorrhage / chemically induced*
  • Cerebral Hemorrhage / complications
  • Cerebral Hemorrhage / diet therapy
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical
  • Isoniazid / adverse effects*
  • Isoniazid / therapeutic use
  • Male
  • Rifampin / adverse effects*
  • Rifampin / therapeutic use
  • Streptomycin / therapeutic use
  • Tuberculosis / complications
  • Tuberculosis / congenital*
  • Tuberculosis / drug therapy*
  • Vitamin K / therapeutic use
  • Vitamin K Deficiency / chemically induced*
  • Vitamin K Deficiency / complications
  • Vitamin K Deficiency / diet therapy

Substances

  • Vitamin K
  • Isoniazid
  • Rifampin
  • Streptomycin