Medline ® Abstract for Reference 93
of 'Renal manifestations of tuberous sclerosis complex'
Two different types of infantile renal cell carcinomas associated with tuberous sclerosis.
Kubo M, Iwashita K, Oyachi N, Oyama T, Yamamoto T
J Pediatr Surg. 2011;46(10):E37.
Renal cell carcinoma (RCC) associated with tuberous sclerosis (TSC) has been reported in adult patients; however, this association is rare in children. We have encountered 2 different types of RCCs in infants who developed TSC later in childhood. The pathologic diagnoses were papillary RCC in one infant and a clear cell-type RCC in the other. Gene analysis showed that both the patients had a mutation in TSC2 gene on chromosome 16.
Department of Pediatric Surgery, Yamanashi Prefectural Central Hospital, Kofu 400-0027, Japan. firstname.lastname@example.org