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Medline ® Abstract for Reference 93

of 'Renal manifestations of tuberous sclerosis complex'

93
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Two different types of infantile renal cell carcinomas associated with tuberous sclerosis.
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Kubo M, Iwashita K, Oyachi N, Oyama T, Yamamoto T
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J Pediatr Surg. 2011;46(10):E37.
 
Renal cell carcinoma (RCC) associated with tuberous sclerosis (TSC) has been reported in adult patients; however, this association is rare in children. We have encountered 2 different types of RCCs in infants who developed TSC later in childhood. The pathologic diagnoses were papillary RCC in one infant and a clear cell-type RCC in the other. Gene analysis showed that both the patients had a mutation in TSC2 gene on chromosome 16.
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Department of Pediatric Surgery, Yamanashi Prefectural Central Hospital, Kofu 400-0027, Japan. m-kubo@kusatsu-gh.or.jp
PMID