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Medline ® Abstract for Reference 113

of 'Renal manifestations of tuberous sclerosis complex'

A case of tuberous sclerosis complex that progressed to end-stage renal disease.
Sarraf M, Masoumi A, Castro-Silva FJ, Myers JB, Wilson SS, Schrier RW
Nat Clin Pract Nephrol. 2009 Mar;5(3):172-6. Epub 2009 Jan 27.
BACKGROUND: A 31-year-old woman with tuberous sclerosis complex presented with a 1 week history of subjective fever, chills, rigors, poor appetite and dizziness.
INVESTIGATIONS: Physical examination, urine and blood analysis, CT of the abdomen, chest and brain, and chest X-ray.
DIAGNOSIS: End-stage renal disease, septic shock and urinary tract infection secondary to huge bilateral angiomyolipomas of the kidney associated with tuberous sclerosis complex.
MANAGEMENT: Antibiotic therapy, vasopressor treatment and bilateral nephrectomy, followed by hemodialysis while awaiting renal transplantation.
Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80220, USA. mohammad.sarraf@uchsc.edu