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Renal angiomyolipomas

Vicente E Torres, MD
William M Bennett, MD
Section Editor
Ronald D Perrone, MD
Deputy Editor
Alice M Sheridan, MD


Angiomyolipomas (AMLs) belong to a family of tumors collectively referred to as neoplasms with perivascular epithelioid differentiation, which were previously called perivascular epithelioid cell tumors and are now referred to as PEComas [1]. These tumors arise by clonal proliferation of epithelioid cells distributed around blood vessels [2].

Renal AMLs may occur in association with tuberous sclerosis complex (TSC) or pulmonary lymphangioleiomyomatosis (LAM), or occur as a sporadic finding among patients who have neither TSC nor pulmonary LAM.

This topic reviews sporadic renal AMLs that occur among patients who do not have TSC and renal AMLS that occur among patients with sporadic pulmonary LAM. Renal AMLs that occur in association with TSC are discussed elsewhere. (See "Renal manifestations of tuberous sclerosis complex", section on 'Angiomyolipomas'.)


Epidemiology — Renal AMLs are found in approximately 0.3 to 2.1 percent of kidneys at routine autopsy [3] and, due to both an increase in the use of imaging and advances in imaging technology, are increasingly identified in the general population as an incidental finding [4-9].

The following findings are from studies that evaluated the frequency of renal AMLs in different groups and used different radiologic techniques:

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Literature review current through: Sep 2017. | This topic last updated: Jul 07, 2015.
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