Marked Sinus Bradycardia Associated With Remdesivir in COVID-19: A Case and Literature Review

JACC Case Rep. 2020 Nov 18;2(14):2260-2264. doi: 10.1016/j.jaccas.2020.08.025. Epub 2020 Oct 28.

Abstract

Remdesivir has seen extensive use during the coronavirus disease-2019 pandemic given its clinically proven efficacy against severe acute respiratory syndrome coronavirus type 2. There has been little cited regarding adverse effects. Here we present the case of a patient with marked sinus bradycardia that began acutely on initiation of remdesivir and resolved almost immediately on cessation of the drug. (Level of Difficulty: Beginner.).

Keywords: AV, atrioventricular; COVID-19, coronavirus disease-2019; ECG, electrocardiogram; LBBB, left bundle branch block; bradycardia; cancer; cardiovascular disease; chest pain; electrocardiogram; electrophysiology; h-mtRNAP, human mitochondrial RNA polymerase; lethargy; physical examination; shortness of breath.

Publication types

  • Case Reports