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Radiation therapy for high-grade gliomas

Helen A Shih, MD
Section Editors
Jay S Loeffler, MD
Patrick Y Wen, MD
Deputy Editor
April F Eichler, MD, MPH


High-grade gliomas are malignant brain tumors that include the most common malignant primary brain tumor in adults, glioblastoma, as well as anaplastic astrocytoma and anaplastic oligodendroglioma. The diffuse gliomas are further subdivided according to isocitrate dehydrogenase (IDH) mutation status and the presence or absence of codeletion of chromosomes 1p and 19q [1]. (See "Classification and pathologic diagnosis of gliomas".)

Most high-grade gliomas are managed with a combined-modality approach, incorporating adjuvant postoperative radiation therapy (RT) and adjuvant chemotherapy following initial surgery. An overview of the use of RT in patients with high-grade glioma is presented here.

Other patient management topics that are covered separately include:

Initial surgical management of high-grade gliomas (see "Clinical presentation, initial surgical approach, and prognosis of high-grade gliomas")

Concurrent and adjuvant chemotherapy (see "Initial postoperative therapy for glioblastoma and anaplastic astrocytoma")

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Literature review current through: Nov 2017. | This topic last updated: Dec 06, 2017.
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