Abstract
Acid aspiration syndrome remains a potentially critical perioperative complication. We compared lafutidine, ranitidine, and rabeprazole for reduction of preoperative gastric fluid acidity and volume in elective surgery and found that these variables were minimized with a single morning dose of lafutidine 20 mg compared with ranitidine or rabeprazole. Preoperative oral lafutidine may be an alternative to ranitidine as a prophylaxis against aspiration pneumonia.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles
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Acetamides / therapeutic use*
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Adult
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Aged
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Anti-Ulcer Agents / therapeutic use*
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Benzimidazoles / therapeutic use*
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Enzyme Inhibitors / therapeutic use*
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Female
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Gastric Acid / physiology*
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Gastric Acidity Determination
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Histamine H2 Antagonists / therapeutic use*
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Humans
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Intraoperative Complications / epidemiology
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Intubation, Gastrointestinal
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Male
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Middle Aged
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Omeprazole / analogs & derivatives
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Piperidines / therapeutic use*
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Preoperative Care*
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Proton Pump Inhibitors
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Pyridines / therapeutic use*
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Rabeprazole
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Ranitidine / therapeutic use*
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Risk Assessment
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Stomach / anatomy & histology
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Stomach / drug effects
Substances
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2-Pyridinylmethylsulfinylbenzimidazoles
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Acetamides
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Anti-Ulcer Agents
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Benzimidazoles
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Enzyme Inhibitors
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Histamine H2 Antagonists
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Piperidines
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Proton Pump Inhibitors
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Pyridines
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Rabeprazole
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lafutidine
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Ranitidine
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Omeprazole