Abstract
Four children with vincristine (VCR)-induced neuropathy are being reported. All cases were followed with the diagnosis of acute lymphoblastic leukemia. Two were boys aged between 2 and 13 year. Electromyographic examination consisted of sensoriomotor polyneuropathy with axonal involvement in three patients. In another patient, it consisted of motor axonal polyneuropathy. In all patients, pyridoxine and pyridostigmine were successfully used in the treatment of VCR-induced neuropathy. They recovered completely with this drug combination. Recovering period of symptoms was between 1-2 week.
MeSH terms
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Adolescent
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / adverse effects*
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Child
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Child, Preschool
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Cholinesterase Inhibitors / therapeutic use*
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Drug Therapy, Combination
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Female
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Humans
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Male
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Polyneuropathies / chemically induced
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Polyneuropathies / diagnosis
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Polyneuropathies / drug therapy*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Pyridostigmine Bromide / therapeutic use*
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Pyridoxine / therapeutic use*
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Treatment Outcome
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Vincristine / administration & dosage
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Vincristine / adverse effects*
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Vitamin B Complex / therapeutic use*
Substances
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Antineoplastic Agents, Phytogenic
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Cholinesterase Inhibitors
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Vitamin B Complex
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Vincristine
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Pyridoxine
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Pyridostigmine Bromide