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Prune-belly syndrome

Manfred Wallner, MD
Reinhard Kramar, MD
Section Editors
F Bruder Stapleton, MD
Laurence S Baskin, MD, FAAP
Deputy Editor
Melanie S Kim, MD


The prune-belly (Eagle-Barrett) syndrome (PBS) is a congenital disorder defined by a characteristic clinical triad (picture 1):

Abdominal muscle deficiency

Severe urinary tract abnormalities

Bilateral cryptorchidism in males

The term "prune-belly" reflects the characteristic wrinkled appearance of the abdominal wall in the newborn due to the complete or partially complete absence of abdominal wall muscles. In adolescent and adult life, the abdomen often assumes a smooth "pot belly" configuration. Contrary to this definition, PBS is in fact a multisystem disease, with patients displaying concomitant cardiopulmonary, gastrointestinal, and musculoskeletal anomalies in varying degree.

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Literature review current through: Nov 2017. | This topic last updated: Apr 20, 2016.
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