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Prothrombin G20210A mutation

Kenneth A Bauer, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD


The prothrombin G20210A mutation is the second most common inherited thrombophilia after the factor V Leiden mutation. Challenging clinical issues include the decisions regarding when to test for the mutation and how to manage individuals with the mutation, either in the setting of venous thromboembolism (VTE) or as an incidental finding.

This topic reviews the diagnosis of prothrombin G20210A and the management of individuals who carry the mutation.

Separate topic reviews discuss other thrombophilias and the role of thrombophilia screening in various populations:

Other thrombophilias:

Factor V Leiden (FVL) mutation – (See "Factor V Leiden and activated protein C resistance".)

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Literature review current through: Sep 2017. | This topic last updated: Apr 18, 2017.
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