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Prognosis and treatment of mixed connective tissue disease

Robert M Bennett, MD, FRCP, MACR
Section Editor
John S Axford, DSc, MD, FRCP, FRCPCH
Deputy Editor
Monica Ramirez Curtis, MD, MPH


Mixed connective tissue disease (MCTD) is a generalized connective tissue disorder that includes clinical features commonly seen in systemic lupus erythematosus (SLE), scleroderma, and polymyositis (referred to as overlap syndrome) (table 1) [1]. Almost any organ system can be involved in MCTD. There are, however, several clinical features that, taken together, suggest the presence of MCTD rather than another connective tissue disorder:

Raynaud phenomenon and swollen hands or puffy fingers

A high titer speckled pattern antinuclear antibody (ANA) (usually ≥1280)

The absence of severe renal and central nervous system (CNS) disease

More severe arthritis, which is sometimes deforming

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Literature review current through: Sep 2017. | This topic last updated: Dec 04, 2015.
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