Abstract
Verbal memory and reaction time of ten schizophrenic patients were compared at two different serum anticholinergic levels. Verbal recall was worse at higher drug levels, while reaction time tended to be improved by anticholinergic treatment. Implications for studies of memory in schizophrenia are considered.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antipsychotic Agents / administration & dosage
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Antipsychotic Agents / adverse effects
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Benztropine / administration & dosage
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Benztropine / adverse effects*
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Chronic Disease
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Dyskinesia, Drug-Induced / drug therapy*
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Dyskinesia, Drug-Induced / psychology
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Female
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Humans
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Male
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Memory, Short-Term / drug effects
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Mental Recall / drug effects*
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Psychiatric Status Rating Scales
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Reaction Time / drug effects
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Schizophrenia / drug therapy*
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Schizophrenic Psychology*
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Trihexyphenidyl / administration & dosage
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Trihexyphenidyl / adverse effects*
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Verbal Learning / drug effects
Substances
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Antipsychotic Agents
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Benztropine
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Trihexyphenidyl