Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers

Eur J Clin Pharmacol. 1980 Jul;18(1):31-42. doi: 10.1007/BF00561476.
No abstract available

MeSH terms

  • Adult
  • Aminopyrine / metabolism
  • Cytochrome P-450 Enzyme System / metabolism
  • Epilepsy / drug therapy
  • Female
  • Half-Life
  • Humans
  • Hydroxylation
  • Infant
  • Infant, Newborn
  • Kinetics
  • Liver / enzymology
  • Male
  • Malonates / metabolism*
  • Maternal-Fetal Exchange*
  • Phenobarbital / metabolism*
  • Phenylethylmalonamide / metabolism*
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Primidone / metabolism*

Substances

  • Malonates
  • Aminopyrine
  • Primidone
  • Phenylethylmalonamide
  • Cytochrome P-450 Enzyme System
  • Phenobarbital