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Primary disorders of phagocytic function: An overview

Francisco A Bonilla, MD, PhD
Section Editor
Luigi D Notarangelo, MD
Deputy Editor
Elizabeth TePas, MD, MS


Susceptibility to infection from phagocytic dysfunction ranges from mild, recurrent skin infections to overwhelming, fatal systemic infection. Affected patients are more susceptible to bacterial and fungal infections but have a normal resistance to viral infections. Most are diagnosed in infancy due to the severity of the infection or the unusual presentation of the organism, but some escape diagnosis until adulthood.

This topic review provides a brief overview of the types of defects and typical presentation of primary phagocytic disorders. The major disorders resulting from defects of phagocytic function are also briefly discussed. (Detailed discussions of these disorders are presented separately. See links in respective sections below.)

A detailed discussion of methods used in the evaluation of immune system function is found separately. (See "Laboratory evaluation of the immune system".)


Phagocytic disorders may be divided into extrinsic and intrinsic defects:

Extrinsic defects include opsonic abnormalities secondary to deficiencies of antibody and complement factors. Extrinsic factors may lead to neutropenia by suppression of granulocyte production or cause a decrease in the number of circulating neutrophils via leukocyte autoantibodies or isoantibodies directed against neutrophil antigens.

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Literature review current through: Nov 2017. | This topic last updated: Apr 05, 2017.
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