Prevention of type 2 diabetes mellitus
- David K McCulloch, MD
David K McCulloch, MD
- Washington Permanente Medical Group
- R Paul Robertson, MD
R Paul Robertson, MD
- Pacific Northwest Research Diabetes Institute
- Professor of Medicine and Pharmacology
- University of Washington
- University of Minnesota
Type 2 diabetes mellitus is characterized by hyperglycemia, insulin resistance, and relative impairment in insulin secretion. Although the lifetime risk of type 2 diabetes is high, our ability to predict and prevent type 2 diabetes in the general population is limited. However, individuals at high risk, including those with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), obesity, close relatives with type 2 diabetes, or who are members of certain ethnic groups (Asian, Hispanic, African American), are appropriate candidates for preventive interventions .
The prevention of type 2 diabetes mellitus will be reviewed here. The prevalence, risk factors, and screening for type 2 diabetes are discussed elsewhere. (See "Risk factors for type 2 diabetes mellitus" and "Screening for type 2 diabetes mellitus".)
GOALS OF DIABETES PREVENTION
The goals of diabetes prevention include:
●Delaying the onset of diabetes
●Preserving beta cell function
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- GOALS OF DIABETES PREVENTION
- OUR APPROACH
- Identify individuals for preventive measures
- Lifestyle modification
- Assess response to lifestyle intervention
- LIFESTYLE INTERVENTION
- - Finnish Diabetes Prevention Study
- - Diabetes Prevention Program
- PHARMACOLOGIC THERAPY
- Choice of drug therapy
- - Metformin
- Drugs not recommended for prevention
- BARIATRIC SURGERY
- SOCIETY GUIDELINE LINKS
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS