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Pregnancy in women with sickle cell disease

Elliott P Vichinsky, MD
Section Editors
Stanley L Schrier, MD
Lynn L Simpson, MD
Deputy Editors
Jennifer S Tirnauer, MD
Vanessa A Barss, MD, FACOG


Although most pregnancies complicated by maternal sickle cell disease (SCD) are likely to result in livebirth, these pregnancies are at increased risk of obstetrical and fetal complications, as well as medical complications of SCD [1-4]. These risks are due, at least in part, to the metabolic demands, hypercoagulable state, and vascular stasis associated with pregnancy. Access to a multidisciplinary care team knowledgeable about sickle cell disease and high-risk obstetrics can significantly decrease morbidity and mortality.

Pregnancy-related issues in management of patients with SCD will be discussed here. General issues regarding clinical features, pathophysiology, diagnosis, and management of SCD are reviewed separately.

(See "Overview of the clinical manifestations of sickle cell disease".)

(See "Mechanisms of vaso-occlusion in sickle cell disease".)

(See "Diagnosis of sickle cell disorders".)

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Literature review current through: Nov 2017. | This topic last updated: Jul 27, 2017.
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