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Medline ® Abstract for Reference 81

of 'Post-endoscopic retrograde cholangiopancreatography (ERCP) septic complications'

Infection after ERCP, and antibiotic prophylaxis: a sequential quality-improvement approach over 11 years.
Cotton PB, Connor P, Rawls E, Romagnuolo J
Gastrointest Endosc. 2008;67(3):471.
BACKGROUND: Infection is a known complication of ERCP procedures, and the role of antibiotic prophylaxis is uncertain.
OBJECTIVE: To document the incidence of infection after ERCP while changing the policy for antibiotic prophylaxis.
DESIGN: Retrospective analysis of data collected prospectively on infection complications, with progressive reduction in the use of prophylactic antibiotics.
SETTING: Single-center university referral hospital.
PATIENTS: A total of 11,484 ERCP procedures were documented prospectively over a period of 11 years.
INTERVENTIONS: After baseline assessment, the use of prophylactic antibiotics was sequentially reduced and simplified in 3 phases.
MAIN OUTCOME MEASUREMENTS: Incidence of infection, categorized by severity.
RESULTS: The infection rate was low overall and decreased significantly with time, from 0.48% to 0.25%, despite a marked reduction in the proportion of patients given antibiotics (from 95% to 25%). Multivariate analysis also showed that the only category of patients at increased risk for infection (despite antibiotics) was the subgroup undergoing interventions for biliary problems after liver transplantation.
LIMITATIONS: A lack of routine follow-up may mean that some delayed infectious complications were not recorded. The low risk of infection in this series may reflect the high technical success rate for relief of biliary obstruction; thus, our current minimalist antibiotic policy may not be generalizable to community practice.
CONCLUSIONS: Infectious complications of ERCP can be kept to a minimum with a limited use of prophylactic antibiotics.
Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA.