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Medline ® Abstract for Reference 171

of 'Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis'

The relaxant action of hymecromone and lignocaine on induced spasm of the bile duct sphincter.
McFarland RJ, Corbett CR, Taylor P, Nash AG
Br J Clin Pharmacol. 1984;17(6):766.
The retained stone in the common bile duct remains a problem for the surgeon. Although more effective methods are available, mechanical flushing of the bile duct is, when successful, a simple solution. Pharmacological dilatation of the sphincter of Oddi is a logical adjunct to flushing. Pressure changes in the bile duct during flushing were studied in 20 postoperative patients with T-tube drains and the effectiveness of two drugs in reducing Omnopon induced spasm of the sphincter was compared. Hymecromone intravenously and lignocaine via the T-tube were equally effective, reducing sphincter activity in the majority of patients, but there was considerable individual variation.