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Medline ® Abstract for Reference 135

of 'Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis'

[Preventive effect of 5-fluorouracil on post-ERCP pancreatitis].
Fan WT, Wang QW, Li QL
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Apr;29(2):201-3.
OBJECTIVE: To investigate the preventive effect of 5-fluorouracil (5-FU) on post-ERCP (endoscopic retrograde cholangiopancreatography) hyperamy-lasemia and pancreatitis.
METHODS: One hundred and sixty patients who underwent ERCP were divided at random into 2 groups: group A (n = 80) was given meglumine diatrizoate with 5-FU; and group B (n = 80) was used contrast medium without 5-FU. Blood was drawn in each group the day before, 6 hours and 24 hours following ERCP for amylase.
RESULTS: Post-ERCP hyperamylasemia occurred in 9 patients in group A (11. 25%) and 45 in B (56.25%). The difference of both groups was notable. Pancreatitis ensued in 2 instances in group A (2.50%) and 8 in group B (10.00%). Their difference was significant.
CONCLUSION: 5-FU added in meglumine diatrizoate is helpful to prevent post-ERCP hyperamylasemia and pancreatitis.
Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 41001 1, China. fanwentao2002@yahoo.com.cn