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Possible prevention and therapy of ischemic acute tubular necrosis

Authors
Tushar A Chopra, MD
Mark D Okusa, MD
Section Editor
Paul M Palevsky, MD
Deputy Editor
Alice M Sheridan, MD

INTRODUCTION

Acute kidney injury (AKI) due to ischemic acute tubular necrosis (ATN) typically lasts 7 to 21 days [1], with most patients returning to or near their previous baseline level of renal function as the necrotic tubular cells regenerate.

Possible preventive and therapeutic measures for ischemic ATN will be reviewed here.

The pathogenesis and prognosis of ATN are discussed separately. (See "Kidney and patient outcomes after acute kidney injury in adults" and "Pathogenesis and etiology of ischemic acute tubular necrosis".)

ACUTE KIDNEY INJURY (AKI) VERSUS ACUTE TUBULAR NECROSIS (ATN)

AKI is characterized by an acute reduction of glomerular filtration rate (GFR) and defined by a rise in the serum creatinine concentration or a decline in urine output that has developed within hours to days (table 1). (See "Definition and staging criteria of acute kidney injury in adults".)

AKI is commonly, though not always, caused by ATN, particularly among critically ill hospitalized patients.

                      
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Literature review current through: Sep 2017. | This topic last updated: May 08, 2017.
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